ZFP36L1 ZFP36 ring finger protein like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZFP36L1provided by HGNC
Official Full Name: ZFP36 ring finger protein like 1provided by HGNC
Primary source: HGNC:HGNC:1107
See related: Ensembl:ENSG00000185650 MIM:601064; AllianceGenome:HGNC:1107
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BRF1; ERF1; cMG1; ERF-1; Berg36; TIS11B; RNF162B
Summary: This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression: Ubiquitous expression in endometrium (RPKM 164.2), ovary (RPKM 123.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q24.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (68787655..68796243, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (62994521..63003244, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (69254372..69262960, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-377-3p exacerbates chronic obstructive pulmonary disease through suppressing ZFP36L1 expression and inducing lung fibroblast senescence.
Title: MicroRNA-377-3p exacerbates chronic obstructive pulmonary disease through suppressing ZFP36L1 expression and inducing lung fibroblast senescence.
ZFP36 ring finger protein like 1 significantly suppresses human coronavirus OC43 replication.
Title: ZFP36 ring finger protein like 1 significantly suppresses human coronavirus OC43 replication.
ZFP36L1 Promotes Gastric Cancer Progression via Regulating JNK and p38 MAPK Signaling Pathways.
Title: ZFP36L1 Promotes Gastric Cancer Progression via Regulating JNK and p38 MAPK Signaling Pathways.
Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1.
Title: Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1.
Zinc Finger Protein ZFP36L1 Inhibits Flavivirus Infection by both 5'-3' XRN1 and 3'-5' RNA-Exosome RNA Decay Pathways.
Title: Zinc Finger Protein ZFP36L1 Inhibits Flavivirus Infection by both 5'-3' XRN1 and 3'-5' RNA-Exosome RNA Decay Pathways.
ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts.
Title: ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts.
ZFP36L1 plays an ambiguous role in the regulation of cell expansion and negatively regulates CDKN1A in chronic myeloid leukemia cells.
Title: ZFP36L1 plays an ambiguous role in the regulation of cell expansion and negatively regulates CDKN1A in chronic myeloid leukemia cells.
Overexpression of microRNA-129-5p in glioblastoma inhibits cell proliferation, migration, and colony-forming ability by targeting ZFP36L1.
Title: Overexpression of microRNA-129-5p in glioblastoma inhibits cell proliferation, migration, and colony-forming ability by targeting ZFP36L1.
Nuclear accumulation of ZFP36L1 is cell cycle-dependent and determined by a C-terminal serine-rich cluster.
Title: Nuclear accumulation of ZFP36L1 is cell cycle-dependent and determined by a C-terminal serine-rich cluster.
ARE-binding protein ZFP36L1 interacts with CNOT1 to directly repress translation via a deadenylation-independent mechanism.
Title: ARE-binding protein ZFP36L1 interacts with CNOT1 to directly repress translation via a deadenylation-independent mechanism.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiple common variants for celiac disease influencing immune gene expression. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-64127 (e-PCR)
- UniSTS:30269

RH68093 (e-PCR)
- UniSTS:75143

RH70919 (e-PCR)
- UniSTS:79515

RH70918 (e-PCR)
- UniSTS:84635

G15966 (e-PCR)
- UniSTS:52394

SHGC-12024 (e-PCR)
- UniSTS:6337

PMC126184P2 (e-PCR)
- UniSTS:270531

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	HDA more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in 3'-UTR-mediated mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell differentiation in thymus	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucocorticoid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to peptide hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to raffinose	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to salt stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to transforming growth factor beta stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in chorio-allantoic fusion	IEA Inferred from Electronic Annotation more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesendoderm development	ISS Inferred from Sequence or Structural Similarity more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mitotic cell cycle phase transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural tube development	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in proepicardium development	IEA Inferred from Electronic Annotation more info
involved_in regulation of B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of keratinocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA 3'-end processing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of mRNA stability	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mRNA stability	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mRNA stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of stem cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in vasculogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mRNA decay activator protein ZFP36L1

Names: EGF-response factor 1; TPA-induced sequence 11b; ZFP36-like 1; butyrate response factor 1; early response factor Berg36; zinc finger protein 36, C3H type-like 1; zinc finger protein 36, C3H1 type-like 1; zinc finger protein, C3H type, 36-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001244698.2 → NP_001231627.1 mRNA decay activator protein ZFP36L1 isoform 1

See identical proteins and their annotated locations for NP_001231627.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) is alternatively spliced at the 3' end, and has a shorter 3' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK024202, BC018340, BQ004874, BQ894292, DA876968, DR423896

Consensus CDS

CCDS9791.1

UniProtKB/Swiss-Prot

Q07352, Q13851

UniProtKB/TrEMBL

B3KNA8

Related

ENSP00000337386.3, ENST00000336440.4

Conserved Domains (2) summary

COG5063
Location:115 → 177

CTH1; CCCH-type Zn-finger protein [General function prediction only]

pfam04553
Location:1 → 105

Tis11B_N; Tis11B like protein, N-terminus
NM_001244701.1 → NP_001231630.1 mRNA decay activator protein ZFP36L1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an additional exon at the 5' end compared to variant 1, that introduces an in-frame upstream AUG, translation from which results in an isoform (2) with a longer N-terminus compared to isoform 1.

Source sequence(s)

BC018340, BM712842, BP353132, BQ004874, BQ894292, DA633985, DR423896, FY210721

UniProtKB/TrEMBL

B3KNA8

Conserved Domains (2) summary

pfam00642
Location:184 → 209

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

pfam04553
Location:72 → 168

Tis11B_N; Tis11B like protein, N terminus
NM_004926.4 → NP_004917.2 mRNA decay activator protein ZFP36L1 isoform 1

See identical proteins and their annotated locations for NP_004917.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1. Variants 1 and 2 encode the same isoform.

Source sequence(s)

AI493871, AK024202, BC018340, BM712842, BQ894292, CN312799, DB522201, DR423896

Consensus CDS

CCDS9791.1

UniProtKB/Swiss-Prot

Q07352, Q13851

UniProtKB/TrEMBL

B3KNA8

Related

ENSP00000388402.2, ENST00000439696.3

Conserved Domains (2) summary

COG5063
Location:115 → 177

CTH1; CCCH-type Zn-finger protein [General function prediction only]

pfam04553
Location:1 → 105

Tis11B_N; Tis11B like protein, N-terminus